The Cyclin Cln1 Controls Polyploid Titan Cell Formation following a Stress-Induced G
<sub>2</sub>
Arrest in Cryptococcus

Sophie Altamirano; Zhongming Li; Man Shun Fu; Minna Ding; Sophie R. Fulton; J. Marina Yoder; Vy Tran; Kirsten Nielsen

doi:10.1128/mBio.02509-21

mBio (Oct 2021)

The Cyclin Cln1 Controls Polyploid Titan Cell Formation following a Stress-Induced G <sub>2</sub> Arrest in Cryptococcus

Sophie Altamirano,
Zhongming Li,
Man Shun Fu,
Minna Ding,
Sophie R. Fulton,
J. Marina Yoder,
Vy Tran,
Kirsten Nielsen

Affiliations

Sophie Altamirano: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Zhongming Li: ORCiD; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Man Shun Fu: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Minna Ding: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Sophie R. Fulton: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
J. Marina Yoder: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Vy Tran: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Kirsten Nielsen: ORCiD; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA

DOI: https://doi.org/10.1128/mBio.02509-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Dysregulation of the cell cycle underlies many human genetic diseases and cancers, yet numerous organisms, including microbes, also manipulate the cell cycle to generate both morphologic and genetic diversity as a natural mechanism to enhance their chances for survival. The eukaryotic pathogen Cryptococcus neoformans

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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