Blood and Lymphatic Cancer: Targets and Therapy (Nov 2023)
Zanubrutinib in Mantle Cell Lymphoma Management: A Comprehensive Review
Abstract
Nada Alsuhebany,1– 3 Congshan Pan,4 Eileen Holovac,5 Brian Do,6 Ali McBride7 1College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia; 2King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; 3King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia; 4Department of Oncology Pharmacy, University of Arizona Cancer Center, Tucson, AZ, USA; 5Department of Oncology Pharmacy, VA Loma Linda Healthcare System, Loma Linda, CA, USA; 6Department of Oncology Pharmacy, Southern Arizona VA Hlth Care, Tucson, AZ, USA; 7WW HEOR Markets, Bristol-Myers Squibb, New York City, NY, USACorrespondence: Nada Alsuhebany, Department of Clinical Pharmacy, College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, PO Box 3660, Riyadh, 11481, Kingdom of Saudi Arabia, Tel +966500828585, Email [email protected]: The pharmacology, pharmacokinetics, pharmacodynamics, clinical efficacy, and safety of zanbrutinib are described.Summary: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma that is typically associated with unfavorable outcomes, and virtually all patients with MCL have refractory or relapsed disease despite aggressive treatment. The treatment paradigm for MCL has transformed dramatically over the past decade owing to rapid advancements in immunotherapy and molecular-targeted therapies. Zanubrutinib, a second-generation Bruton’s tyrosine kinase inhibitor (BTKI) designated for mature B-cell non-Hodgkin’s lymphoma (NHL), has drastically improved the survival outcomes in relapsed/refractory (R/R) MCL patients. This selective BTKI is a small molecule that functions by forming a covalent bond in the active site of BTK. The inhibition of BTK activity is essential for the signaling of B-cell antigen receptor (BCR) and cytokine receptor pathways. In a preclinical study, zanubrutinib inhibited malignant B-cell proliferation and reduced tumor growth. Zanubrutinib was granted FDA-accelerated approval based on the results of Phase I and II trials. The investigator-assessed overall response rate was 83.7%, of which 78% of patients achieved complete response. The median duration of response was 19.5 months, and the median progression-free survival was 22.1 months. The most common (≥ 20%) all-grade adverse events were low neutrophil count (46.5%), upper respiratory tract infection (38.4%), rash (36.0%), low white blood cell count (33.7%), and low platelet count (32.6%).Conclusion: Zanubrutinib is a selective, next-generation, orally active, irreversible BTK inhibitor. The selectivity of zanubrutinib and its superior efficacy, with a well-tolerated safety profile, have proven to be attractive options for other malignancies.Keywords: zanubrutinib, mantle cell lymphoma, Bruton’s tyrosine kinase inhibitor
