Risk Management and Healthcare Policy (Nov 2020)
Risk Factors of Prolonged Nausea and Vomiting During Pregnancy
Abstract
Huishan Zhang,1 Shuzhen Wu,2 Jingping Feng,2 Zhengping Liu1,2 1Foshan Fetal Medicine Research Institute, Foshan Women and Children Hospital Affiliated to Southern Medical University, Foshan, Guangdong, People’s Republic of China; 2Department of Obstetrics, Foshan Women and Children Hospital Affiliated to Southern Medical University, Foshan, Guangdong, People’s Republic of ChinaCorrespondence: Zhengping LiuDepartment of Obstetrics, Foshan Women and Children Hospital Affiliated to Southern Medical University, No. 11 Renminxi Road, Foshan, Guangdong 528000, People’s Republic of ChinaTel +86 757 82960793Email [email protected]: Determination of the risk factors associated with prolonged nausea and vomiting during pregnancy (NVP) helps to develop prevention strategies. However, there is a lack of studies regarding risk factors of prolonged NVP. Thus, the potential risk factors of prolonged moderate and severe NVP were examined.Methods: This is a retrospective study among pregnant women in South of China. The Pregnancy-Unique Quantification of Emesis (PUQE) scale was used to evaluate NVP. Onset before 12 weeks and persistence after 20 weeks of gestation were defined as prolonged NVP. Data on NVP and other variables were collected by standard questionnaires and medical records.Results: A finally sample of 1739 participants were analyzed. The incidence of prolonged moderate and severe NVP was 42.1% and 1.1%, respectively. Among those with NVP, the increased risk of prolonged moderate NVP was associated with lower gestational age (OR = 0.95 per SD increase, 95% CI=0.93– 0.97), being a housewife (OR = 1.30, 95% CI=1.02– 1.65), pre-pregnant longer sedentary time (OR = 2.02, 95% CI=1.16– 1.83), pre-pregnant lower exercise frequency (OR = 1.84, 95% CI=1.20– 2.82), and history of gastrointestinal (GI) diseases (OR = 2.21, 95% CI=1.61– 3.03). Persons who were a housewife (OR = 6.39, 95% CI=1.90– 21.47), with pre-pregnant high frequent (always) cold drinking (OR=11.12, 95% CI=1.24– 100.73), and had a history of GI diseases (OR=10.10, 95% CI=2.63– 38.86) were more likely to experience prolonged severe NVP.Conclusion: The results of the present study suggested that pregnant women unemployed, with lower gestational age, pre-pregnant longer sedentary time, less exercise, high frequent (always) cold drinking and history of GI diseases had a higher risk of prolonged NVP and should be taken more care.Keywords: prolonged nausea and vomiting during pregnancy, risk factors, pregnant women, retrospective analysis
