Diabetology & Metabolic Syndrome (Jun 2022)

Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats

  • Matheus Camargos de Britto Rosa,
  • Paula Reis Ribeiro,
  • Viviam de Oliveira Silva,
  • Danubia Aparecida de Carvalho Selvati-Rezende,
  • Tácio Peres da Silva,
  • Fernanda Rezende Souza,
  • Maria das Graças Cardoso,
  • Josilene Nascimento Seixas,
  • Eric Francelino Andrade,
  • Vanessa Pardi,
  • Ramiro Mendonça Murata,
  • Luciano José Pereira

DOI
https://doi.org/10.1186/s13098-022-00847-4
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

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Abstract Background Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce. Objective To evaluate the effects of CN ingestion in obese rats. Design Thirty animals (obese and non-obese) received one of three different types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose—called 2CN. Treatment was maintained for 28 days. Results The fatty acid profile of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p 0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononuclear leucocyte infiltrate. Conclusions Although CN presented beneficial effects on the metabolism of rats, it also caused increased risk of liver damage.

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