Nature Communications (Oct 2022)
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota
- Lucas Moitinho-Silva,
- Frauke Degenhardt,
- Elke Rodriguez,
- Hila Emmert,
- Simonas Juzenas,
- Lena Möbus,
- Florian Uellendahl-Werth,
- Nicole Sander,
- Hansjörg Baurecht,
- Lukas Tittmann,
- Wolfgang Lieb,
- Christian Gieger,
- Annette Peters,
- David Ellinghaus,
- Corinna Bang,
- Andre Franke,
- Stephan Weidinger,
- Malte Christoph Rühlemann
Affiliations
- Lucas Moitinho-Silva
- Institute of Clinical Molecular Biology, Kiel University
- Frauke Degenhardt
- Institute of Clinical Molecular Biology, Kiel University
- Elke Rodriguez
- Department of Dermatology and Allergy, University Hospital Schleswig-Holstein
- Hila Emmert
- Department of Dermatology and Allergy, University Hospital Schleswig-Holstein
- Simonas Juzenas
- Institute of Clinical Molecular Biology, Kiel University
- Lena Möbus
- Department of Dermatology and Allergy, University Hospital Schleswig-Holstein
- Florian Uellendahl-Werth
- Institute of Clinical Molecular Biology, Kiel University
- Nicole Sander
- Department of Dermatology and Allergy, University Hospital Schleswig-Holstein
- Hansjörg Baurecht
- Department for Epidemiology and Preventive Medicine, University of Regensburg
- Lukas Tittmann
- Biobank PopGen and Institute of Epidemiology, Kiel University
- Wolfgang Lieb
- Institute of Epidemiology, Kiel University
- Christian Gieger
- Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health
- David Ellinghaus
- Institute of Clinical Molecular Biology, Kiel University
- Corinna Bang
- Institute of Clinical Molecular Biology, Kiel University
- Andre Franke
- Institute of Clinical Molecular Biology, Kiel University
- Stephan Weidinger
- Department of Dermatology and Allergy, University Hospital Schleswig-Holstein
- Malte Christoph Rühlemann
- Institute of Clinical Molecular Biology, Kiel University
- DOI
- https://doi.org/10.1038/s41467-022-33906-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Microbiome composition is influenced by genetics, although the specific host genetic factors responsible are not well known. Here, the authors performed a genome-wide meta-analysis to discover host genetic effects on skin microbiota and finding potential causal effects of microbiota composition on skin diseases.
