Nature Communications (May 2016)
TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
- Sayaka Aizawa,
- Toru Okamoto,
- Yukari Sugiyama,
- Takahisa Kouwaki,
- Ayano Ito,
- Tatsuya Suzuki,
- Chikako Ono,
- Takasuke Fukuhara,
- Masahiro Yamamoto,
- Masayasu Okochi,
- Nobuhiko Hiraga,
- Michio Imamura,
- Kazuaki Chayama,
- Ryosuke Suzuki,
- Ikuo Shoji,
- Kohji Moriishi,
- Kyoji Moriya,
- Kazuhiko Koike,
- Yoshiharu Matsuura
Affiliations
- Sayaka Aizawa
- Department of Molecular Virology, Osaka University
- Toru Okamoto
- Department of Molecular Virology, Osaka University
- Yukari Sugiyama
- Department of Molecular Virology, Osaka University
- Takahisa Kouwaki
- Department of Molecular Virology, Osaka University
- Ayano Ito
- Department of Molecular Virology, Osaka University
- Tatsuya Suzuki
- Department of Molecular Virology, Osaka University
- Chikako Ono
- Department of Molecular Virology, Osaka University
- Takasuke Fukuhara
- Department of Molecular Virology, Osaka University
- Masahiro Yamamoto
- Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University
- Masayasu Okochi
- Department of Integrated Medicine, Neuropsychiatry and Neurochemistry, Osaka University
- Nobuhiko Hiraga
- Department of Medicine and Molecular Science, Hiroshima University School of Medicine
- Michio Imamura
- Department of Medicine and Molecular Science, Hiroshima University School of Medicine
- Kazuaki Chayama
- Department of Medicine and Molecular Science, Hiroshima University School of Medicine
- Ryosuke Suzuki
- Department of Virology II, National Institute of Infectious Diseases
- Ikuo Shoji
- Division of Infectious Diseases Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine
- Kohji Moriishi
- Department of Microbiology, Faculty of Medicine, University of Yamanashi
- Kyoji Moriya
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Kazuhiko Koike
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Yoshiharu Matsuura
- Department of Molecular Virology, Osaka University
- DOI
- https://doi.org/10.1038/ncomms11379
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immature core protein mediated by the E3 ubiquitin ligase TRC8.
