ARMMs as a versatile platform for intracellular delivery of macromolecules

Qiyu Wang; Jiujiu Yu; Tatenda Kadungure; Joseph Beyene; Hong Zhang; Quan Lu

doi:10.1038/s41467-018-03390-x

Nature Communications (Mar 2018)

ARMMs as a versatile platform for intracellular delivery of macromolecules

Qiyu Wang,
Jiujiu Yu,
Tatenda Kadungure,
Joseph Beyene,
Hong Zhang,
Quan Lu

Affiliations

Qiyu Wang: Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health
Jiujiu Yu: Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health
Tatenda Kadungure: Department of Pediatrics, Division of Genes and Development, University of Massachusetts Medical School
Joseph Beyene: Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health
Hong Zhang: Department of Pediatrics, Division of Genes and Development, University of Massachusetts Medical School
Quan Lu: Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health

DOI: https://doi.org/10.1038/s41467-018-03390-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 7

Abstract

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One of the challenges of biologic drug therapy is delivery into target cells and tissues. Here the authors present ARMMs (arrestin domain containing protein 1 mediated microvesicles) as a versatile platform for packaging and delivery of a myriad of molecules, including p53, RNAs and CRISPR-Cas9.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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