Acta Medica Iranica (Dec 2006)
THE EFFECT OF INTRAVENOUS NITRIGLYCERINE ON UTERINE RELAXATION IN EMERGENCY CESAREAN SECTION
Abstract
Nitroglycerin has a relaxing effect on the smooth muscles of organs including uterus. This study investigates the effect of intravenous nitroglycerin in emergency cesarean sections in which rapid and transient uterine relaxation for rapid and nontraumatic extraction of the fetus is necessary. Sixty pregnant women who were been candidates for emergency cesarean and needed rapid uterine relaxation for different reasons were selected. These subjects underwent spinal anesthesia and at the time of uterine incision, 100 micrograms of nitroglycerin was injected to them intravenously. The time lapse between nitroglycerin administration and fetal extraction, the degree of uterine relaxation, the amount of intraoperative hemorrhage, uterine tone after fetal delivery and APGAR scores of the infants were all controlled and recorded. The results showed that in 53 (88.3%) of patients the uterus was acceptably relaxed and the fetus was delivered very easily. Only in 7 patients (11.7%) uterine relaxation was not acceptable. The mean decrease in systolic and diastolic blood pressures after nitroglycerin administration compared with before injection BP was 12.96 mmHg and 7.86 mmHg, respectively. There was not any prolonged effect of the drug such as uterus relaxation tone or abnormal bleeding. Also none of the delivered infants had low APGAR scores. Besides, in patients with acceptable uterine relaxation the first and fifth minute APGAR score of infants were higher (P = 0.008 and P = 0.000), respectively. This study shows that nitroglycerin can relax uterine smooth muscles very rapidly and transiently and in emergencies it can be an appropriate alternative to other tocolytic agents with prolonged effect or onset time.
