Nature Communications (Apr 2017)

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

  • Sophie Leclercq,
  • Firoz M. Mian,
  • Andrew M. Stanisz,
  • Laure B. Bindels,
  • Emmanuel Cambier,
  • Hila Ben-Amram,
  • Omry Koren,
  • Paul Forsythe,
  • John Bienenstock

DOI
https://doi.org/10.1038/ncomms15062
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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There is concern about potential long-term effects of antibiotics on children’s health. Here Leclercqet al. show, in mice, that low doses of penicillin during late pregnancy and early life induce lasting effects on the offspring, including alterations in gut microbiota, brain cytokine levels and behaviour.