Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease

Yizhou Wen; Xianmin Wang; Yonghong Guo; Mei Jin; Jimei Xi; Tingting Chen; Kun Shi; Yaheng Lu

doi:10.1038/s41598-021-87704-y

Scientific Reports (Apr 2021)

Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease

Yizhou Wen,
Xianmin Wang,
Yonghong Guo,
Mei Jin,
Jimei Xi,
Tingting Chen,
Kun Shi,
Yaheng Lu

Affiliations

Yizhou Wen: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Xianmin Wang: Sichuan Women’s and Children’s Hospital, Women’s and Children’s Hospital Affiliated to Chengdu Medical College
Yonghong Guo: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Mei Jin: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Jimei Xi: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Tingting Chen: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Kun Shi: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Yaheng Lu: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China

DOI: https://doi.org/10.1038/s41598-021-87704-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

Read online

Abstract Coronary artery abnormalities (CAAs) are a severe complication of Kawasaki disease (KD) that may lead to cardiovascular events. Given the evidence that brachial artery flow-mediated dilation (FMD) decreases in children after the onset of KD, we hypothesized that it could be an early marker of CAA development in the acute stage and investigated its relationship with variation in the coronary artery diameter. A total of 326 sex- and age-matched children were enrolled, including 120 with KD, 109 febrile children and 97 healthy controls. In this study, FMD was significantly decreased in the KD group compared with the febrile and healthy groups. FMD was lower in the CAA group than in the no coronary artery abnormality group. The comparison of FMD showed an obvious difference among the CAA subgroups. The FMD in the coronary aneurysm (CA) group showed a strong negative correlation with the pretreatment maximum coronary artery Z-score (preZmax). While preZmax was 2.5, the receiver operating characteristic curve indicated an optimal cutoff point of 3.44% for FMD. FMD ≤ 3.44% could be considered as a signal of coronary lesions in acute stage of KD.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

About the journal