Nature Communications (Feb 2017)

Self-organizing actin patterns shape membrane architecture but not cell mechanics

  • M. Fritzsche,
  • D. Li,
  • H. Colin-York,
  • V. T. Chang,
  • E. Moeendarbary,
  • J. H. Felce,
  • E. Sezgin,
  • G. Charras,
  • E. Betzig,
  • C. Eggeling

DOI
https://doi.org/10.1038/ncomms14347
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

In vitro models of actin organization show the formation of vortices, asters and stars. Here Fritzsche et al. show that such actin structures form in living cells in a manner dependent on the Arp2/3 complex but not myosin, and such structures influence membrane architecture but not cortex elasticity.