The effect of subcutaneous unfractionated heparin and low-molecular weight heparin toward modification of diabetic acute influence on surgical wound healing in rats

Abstract

Background and Objectives: Diabetes mellitus is one of the disturbing factors in surgical wound repair that recognizing these mechanisms, and modifying them can be useful in preventing surgical wound complications. The aim of this study is to assess the effect of unfractionated heparin (UH) and low-molecular weight heparin (LMWH) on diabetic wounds in the rats. Materials and Methods: This study as a clinical trial in the animal phase was done in two groups that each group consists of three subgroups containing eight rats in each. Initially, under anesthesia, the skin was incised surgically, and interventions with UH in the first subgroup of each group, LMWH in the second subgroup, and normal saline in the third subgroup were performed. In the first group on the 7th day and the second group on the 10th day, wound biopsy was taken and examined pathologically. Finally, data were analyzed using Kruskal–Wallis and one-way analysis of variance statically test. Results: The results of this study showed in every two groups, there was a statistically significant difference between the subgroups for fibroblast and vascularity status, but this difference was not significant for epithelialization and collagen level. In addition, wound length in both the groups had a significant difference between subgroups. Conclusion: In this study, there was a relative difference between the administration of UH and low-molecular weight and surgical wound healing in diabetic rats.

Keywords

• diabetes
• heparin
• surgical wound healing