Nature Communications (Oct 2019)
Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
- Jon Cantero-Pérez,
- Judith Grau-Expósito,
- Carla Serra-Peinado,
- Daniela A. Rosero,
- Laura Luque-Ballesteros,
- Antonio Astorga-Gamaza,
- Josep Castellví,
- Tamara Sanhueza,
- Gustavo Tapia,
- Belen Lloveras,
- Marco A. Fernández,
- Julia G. Prado,
- Josep M. Solé-Sedeno,
- Antoni Tarrats,
- Carla Lecumberri,
- Laura Mañalich-Barrachina,
- Cristina Centeno-Mediavilla,
- Vicenç Falcó,
- Maria J. Buzon,
- Meritxell Genescà
Affiliations
- Jon Cantero-Pérez
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Judith Grau-Expósito
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Carla Serra-Peinado
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Daniela A. Rosero
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Laura Luque-Ballesteros
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Antonio Astorga-Gamaza
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Josep Castellví
- Pathology Department, Hospital Universitari Vall d’Hebron, UAB
- Tamara Sanhueza
- Pathology Department, Hospital Universitari Germans Trias i Pujol, Badalona
- Gustavo Tapia
- Pathology Department, Hospital Universitari Germans Trias i Pujol, Badalona
- Belen Lloveras
- Pathology Department, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma de Barcelona
- Marco A. Fernández
- Flow Cytometry Facility, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol
- Julia G. Prado
- AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona
- Josep M. Solé-Sedeno
- Obstetrics and Gynecology Department, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma de Barcelona
- Antoni Tarrats
- Department of Obstetrics and Gynecology, Hospital Universitari Germans Trias i Pujol, Badalona
- Carla Lecumberri
- Department of Obstetrics and Gynecology, Hospital Universitari Germans Trias i Pujol, Badalona
- Laura Mañalich-Barrachina
- Department of Obstetrics and Gynecology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona
- Cristina Centeno-Mediavilla
- Department of Obstetrics and Gynecology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona
- Vicenç Falcó
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Maria J. Buzon
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- Meritxell Genescà
- Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona
- DOI
- https://doi.org/10.1038/s41467-019-12732-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Using cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in the cervical mucosa.
