PLoS ONE (Jan 2021)

Improvement of renal function after transcatheter aortic valve replacement in patients with chronic kidney disease.

  • Michel V Lemes da Silva,
  • Antonio C B Nunes Filho,
  • Vitor E E Rosa,
  • Adriano Caixeta,
  • Pedro A Lemos Neto,
  • Henrique B Ribeiro,
  • Breno O Almeida,
  • José Mariani,
  • Carlos M Campos,
  • Alexandre A C Abizaid,
  • José A Mangione,
  • Roney O Sampaio,
  • Paulo Caramori,
  • Rogério Sarmento-Leite,
  • Flávio Tarasoutchi,
  • Marcelo Franken,
  • Fábio S de Brito

DOI
https://doi.org/10.1371/journal.pone.0251066
Journal volume & issue
Vol. 16, no. 5
p. e0251066

Abstract

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BackgroundChronic kidney disease is commonly found in patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) and has marked impact in their prognosis. It has been shown however that TAVR may improve renal function by alleviating the hemodynamic barrier imposed by AS. Nevertheless, the predictors of and clinical consequences of renal function improvement are not well established. Our aim was to assess the predictors of improvement of renal function after TAVR.MethodsThe present work is an analysis of the Brazilian Registry of TAVR, a national non-randomized prospective study with 22 Brazilian centers. Patients with baseline renal dysfunction (estimated glomerular filtration rate [eGFR] 10% in eGFR were classified as TAVR induced renal function improvement (TIRFI); decrease > 10% in eGFR were classified as acute kidney injury (AKI) and stable renal function (neither criteria).ResultsA total of 819 consecutive patients with symptomatic severe AS were included. Of these, baseline renal dysfunction (estimated glomerular filtration rate [eGFR] ConclusionsTIRFI was frequently found among baseline impaired renal function individuals but was not associated with improved 1-year outcomes.