Nature Communications (Feb 2023)
Amniotes co-opt intrinsic genetic instability to protect germ-line genome integrity
- Yu H. Sun,
- Hongxiao Cui,
- Chi Song,
- Jiafei Teng Shen,
- Xiaoyu Zhuo,
- Ruoqiao Huiyi Wang,
- Xiaohui Yu,
- Rudo Ndamba,
- Qian Mu,
- Hanwen Gu,
- Duolin Wang,
- Gayathri Guru Murthy,
- Pidong Li,
- Fan Liang,
- Lei Liu,
- Qing Tao,
- Ying Wang,
- Sara Orlowski,
- Qi Xu,
- Huaijun Zhou,
- Jarra Jagne,
- Omer Gokcumen,
- Nick Anthony,
- Xin Zhao,
- Xin Zhiguo Li
Affiliations
- Yu H. Sun
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- Hongxiao Cui
- College of Animal Science and Technology, Northwest A&F University
- Chi Song
- College of Public Health, Division of Biostatistics, The Ohio State University
- Jiafei Teng Shen
- International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine
- Xiaoyu Zhuo
- Department of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine
- Ruoqiao Huiyi Wang
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- Xiaohui Yu
- College of Animal Science and Technology, Northwest A&F University
- Rudo Ndamba
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- Qian Mu
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- Hanwen Gu
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- Duolin Wang
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- Gayathri Guru Murthy
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- Pidong Li
- Grandomics Biosciences Co., Ltd
- Fan Liang
- Grandomics Biosciences Co., Ltd
- Lei Liu
- Grandomics Biosciences Co., Ltd
- Qing Tao
- Grandomics Biosciences Co., Ltd
- Ying Wang
- Department of Animal Science, University of California
- Sara Orlowski
- Department of Poultry Science, University of Arkansas
- Qi Xu
- Department of Animal Science, McGill University
- Huaijun Zhou
- Department of Animal Science, University of California
- Jarra Jagne
- Animal Health Diagnostic Center, Cornell University College of Veterinary Medicine
- Omer Gokcumen
- Department of Biological Sciences, University at Buffalo, State University of New York
- Nick Anthony
- Department of Poultry Science, University of Arkansas
- Xin Zhao
- Department of Animal Science, McGill University
- Xin Zhiguo Li
- Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center
- DOI
- https://doi.org/10.1038/s41467-023-36354-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Pachytene Piwi-interacting RNAs (piRNAs) expressed in mammalian germ lines are abundant, but their evolution and function are not fully understood. Here, the authors find that pachytene piRNA loci are hotspots of structural variation, which underlies rapid piRNA birth, divergence, and loss.
