Association of rs763780 variation in interleukin 17F gene with the risk of knee osteoarthritis

Abstract

Background: The injuries in osteoarthritis are mediated by various cytokines, growth factors, and inflammatory factors and the importance of the interleukin 17 family in this disease is increasingly evident. The aim of this study was to investigate the association between interleukin 17F rs763780 gene variation and the risk of knee osteoarthritis. Materials and Methods: In this case-control study, 200 participants including 100 healthy individuals and 100 patients with knee osteoarthritis referred to Shahid Beheshti hospital were enrolled. The blood samples of the participants were collected and genotypes of the samples in the polymorphic region were detected by PCR-RFLP. Results: Results showed that there was a significant association between the genotype AG and an increased risk of knee osteoarthritis (OR=3.49, 95%CI=1.48-8.25, P<0.01). But, no significant association was found between the genotype GG and an increased risk of knee osteoarthritis. In addition, there was a significant association between the allele G and the risk of knee osteoarthritis (OR=2.97, 95% CI=1.39-6.30, P<0.01). Conclusion: Findings of the present study show that rs763780 can be a risk factor for knee osteoarthritis. Therefore, this polymorphism can be considered as a possible biomarker for the screening of susceptible individuals to knee osteoarthritis.

Keywords

• Knee osteoarthritis
• Interleukin 17
• Genetic polymorphism
• PCR-RFLP