Nature Communications (Feb 2023)

Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM

  • Hyuk-Joon Lee,
  • Hyung Jin Cha,
  • Hyeongseop Jeong,
  • Seu-Na Lee,
  • Chang-Won Lee,
  • Minsoo Kim,
  • Jejoong Yoo,
  • Jae-Sung Woo

DOI
https://doi.org/10.1038/s41467-023-36593-y
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 18

Abstract

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Gap junction intercellular channels (GJIChs) facilitate direct communication between adjacent cells. Here, authors provide high-resolution information on dynamic structural changes in Cx43 GJICh that are necessary to understand the gating mechanism.