Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis

Peter J Anderson, PhD; Debora Marques de Miranda, MD; Maicon Rodrigues Albuquerque, PhD; Marit Sæbø Indredavik, PhD; Kari Anne I. Evensen, PhD; Ryan Van Lieshout, MD; Saroj Saigal, MD; H. Gerry Taylor, PhD; Katri Raikkonen, PhD; Eero Kajantie, DMedSc; Neil Marlow, DM; Samantha Johnson, PhD; Lianne J. Woodward, PhD; Nicola Austin, DM; Chiara Nosarti, PhD; Julia Jaekel, PhD; Dieter Wolke, PhD; Jeanie LY Cheong, MD; Alice Burnett, PhD; Karli Treyvaud, PhD; Katherine J Lee, PhD; Lex W Doyle, MD

EClinicalMedicine (Dec 2021)

Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis

Peter J Anderson, PhD,
Debora Marques de Miranda, MD,
Maicon Rodrigues Albuquerque, PhD,
Marit Sæbø Indredavik, PhD,
Kari Anne I. Evensen, PhD,
Ryan Van Lieshout, MD,
Saroj Saigal, MD,
H. Gerry Taylor, PhD,
Katri Raikkonen, PhD,
Eero Kajantie, DMedSc,
Neil Marlow, DM,
Samantha Johnson, PhD,
Lianne J. Woodward, PhD,
Nicola Austin, DM,
Chiara Nosarti, PhD,
Julia Jaekel, PhD,
Dieter Wolke, PhD,
Jeanie LY Cheong, MD,
Alice Burnett, PhD,
Karli Treyvaud, PhD,
Katherine J Lee, PhD,
Lex W Doyle, MD

Affiliations

Peter J Anderson, PhD: Turner Institute for Brain & Mental Health, Monash University, Clayton, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Corresponding to: PJ Anderson, Turner Institute for Brain & Mental Health, School of Psychological Sciences, 18 Innovation Walk, Monash University, Clayton, 3800, Australia
Debora Marques de Miranda, MD: Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Maicon Rodrigues Albuquerque, PhD: Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Marit Sæbø Indredavik, PhD: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
Kari Anne I. Evensen, PhD: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway; Unit for Physiotherapy Services, Trondheim Municipality, Trondheim, Norway; Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway
Ryan Van Lieshout, MD: Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Saroj Saigal, MD: Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
H. Gerry Taylor, PhD: Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Katri Raikkonen, PhD: Department of Psychology and Logopedics, University of Helsinki, Finland
Eero Kajantie, DMedSc: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway; Finnish Institute for Health and Welfare, Public Health Promotion Unit, Helsinki and Oulu, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu; Children's Hospital, Helsinki University Hospital and University of Helsinki, Finland
Neil Marlow, DM: UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK
Samantha Johnson, PhD: Department of Health Sciences, University of Leicester, Leicester, UK
Lianne J. Woodward, PhD: School of Health Sciences & Child Wellbeing Institute, University of Canterbury, Christchurch, New Zealand
Nicola Austin, DM: Department of Paediatrics, University of Otago, Christchurch, New Zealand
Chiara Nosarti, PhD: Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom
Julia Jaekel, PhD: Psychology, University of Oulu, Finland; Department of Psychology and Division of Health Sciences, University of Warwick, UK
Dieter Wolke, PhD: Department of Psychology and Division of Health Sciences, University of Warwick, UK
Jeanie LY Cheong, MD: Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia; Neonatal Services, Royal Women's Hospital, Parkville, Victoria, Australia
Alice Burnett, PhD: Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia
Karli Treyvaud, PhD: Murdoch Children's Research Institute, Parkville, Victoria, Australia; School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia
Katherine J Lee, PhD: Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
Lex W Doyle, MD: Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia; Neonatal Services, Royal Women's Hospital, Parkville, Victoria, Australia

Journal volume & issue: Vol. 42
p. 101216

Abstract

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Background: Data on psychiatric disorders in survivors born very preterm (VP; 2499 g and/or gestational age ≥37 weeks), and 3) structured measure of psychiatric diagnoses using DSM or ICD criteria. Diagnoses of interest were Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Anxiety Disorder, Mood Disorder, Disruptive Behaviour Disorder (DBD), Eating Disorder, and Psychotic Disorder. A systematic search for eligible studies was conducted (PROSPERO Registration Number 47555). Findings: Data were obtained from 10 studies (1385 VP/VLBW participants, 1780 controls), using a range of instruments and approaches to assigning diagnoses. Those born VP/VLBW had ten times higher odds of meeting criteria for ASD (odds ratio [OR] 10·6, 95% confidence interval [CI] 2·50, 44·7), five times higher odds of meeting criteria for ADHD (OR 5·42, 95% CI 3·10, 9·46), twice the odds of meeting criteria for Anxiety Disorder (OR 1·91, 95% CI 1·36, 2·69), and 1·5 times the odds of meeting criteria for Mood Disorder (OR 1·51, 95% CI 1·08, 2·12) than controls. This pattern of findings was consistent within age (<18 years vs. ≥18 years) and sex subgroups. Interpretation: Our data suggests that individuals born VP/VLBW might have higher odds of meeting criteria for certain psychiatric disorders through childhood and into adulthood than term/NBW controls. Further research is needed to corroborate our results and identify factors associated with psychiatric disorders in individuals born VP/VLBW. Funding: Australia's National Health & Medical Research Council; CAPES (Coordenação de Aperfeiçoamento de Pessoal deNível Superior) - International Cooperation General Program; Canadian Institutes of Health Research Team Grant; National Council for Scientific and Technological Development (CNPq); Academy of Finland; Sigrid Juselius Foundation; Signe and Ane Gyllenberg Foundation; European Union's Horizon 2020 research and innovation programme: Project RECAP-Preterm; European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL); Neurologic Foundation of New Zealand; MRC programme grant; Health Research Council of New Zealand; National Institutes of Health, USA; The Research Council of Norway; Joint Research Committee between St. Olavs Hospital and Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU); Liaison Committee between Central Norway Regional Health Authority and NTNU.

Published in EClinicalMedicine

ISSN: 2589-5370 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://www.thelancet.com/journals/eclinm/home

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