Nature Communications (Dec 2022)

Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration

  • Yu Xia,
  • Sierra Duca,
  • Björn Perder,
  • Friederike Dündar,
  • Paul Zumbo,
  • Miaoyan Qiu,
  • Jun Yao,
  • Yingxi Cao,
  • Michael R. M. Harrison,
  • Lior Zangi,
  • Doron Betel,
  • Jingli Cao

DOI
https://doi.org/10.1038/s41467-022-35433-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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The epicardium supports heart regeneration, though precisely how is unclear. Here the authors define an activated epicardial progenitor population as the source of essential cell types and paracrine factors for successful heart regeneration in zebrafish.