Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus

Tong Wang; Tong Wang; Ling Xu; Ling Xu; Bin Zhu; Bin Zhu; Junzhong Wang; Junzhong Wang; Xin Zheng; Xin Zheng

doi:10.3389/fimmu.2022.937684

Frontiers in Immunology (Jul 2022)

Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus

Tong Wang,
Tong Wang,
Ling Xu,
Ling Xu,
Bin Zhu,
Bin Zhu,
Junzhong Wang,
Junzhong Wang,
Xin Zheng,
Xin Zheng

Affiliations

Tong Wang: Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Tong Wang: Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China
Ling Xu: Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Ling Xu: Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China
Bin Zhu: Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Bin Zhu: Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China
Junzhong Wang: Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Junzhong Wang: Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China
Xin Zheng: Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xin Zheng: Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China

DOI: https://doi.org/10.3389/fimmu.2022.937684
Journal volume & issue: Vol. 13

Abstract

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Severe fever with thrombocytopenia syndrome (SFTS), which is caused by SFTS virus (SFTSV), poses a serious threat to global public health, with high fatalities and an increasing prevalence. As effective therapies and prevention strategies are limited, there is an urgent need to elucidate the pathogenesis of SFTS. SFTSV has evolved several mechanisms to escape from host immunity. In this review, we summarize the mechanisms through which SFTSV escapes host immune responses, including the inhibition of innate immunity and evasion of adaptive immunity. Understanding the pathogenesis of SFTS will aid in the development of new strategies for the treatment of this disease.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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