EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE

Abstract

Aim. To study the influence of polymorphism of the gene methyltetrahydrofolate-reductase (MTHFR) — polymorhic locus С677Т, and level of homocysteine in blood plasma on the risk of development and course of chronic heart failure (CHF).Material and methods. Totally, 277 persons studied with CHF II-IV functional classes (FC NYHA). The polymorphism С677Т of gene MTHFR studied via polymerase chain reaction. With the aim to reveal association of homocysteine with the course of CHF patients were selected by the results of year-long observation to 2 groups: with benign (n=49) and adverse (n=45) course. During the period the following was assessed: increase of symptoms and severity of CHF, hospitalizations rate, dynamics of the left ventricle ejection fraction.Results. Carriage of allele T and genotype T/T of polymorphic locus С677Т gene MTHFR was associated with more severe clinical picture of CHF. In CHF patients of II-IV FC homocysteine concentration in serum was significantly, 2-3 times, higher comparing to the controls, regardless of age. In adverse course group the level was highest comparing to benign course.Conclusion. The relation revealed of hyperhomocysteinemia with severity and character of CHF course. Assessment of homocysteine level in serum, and genetic polymorphism С677Т of gene MTHFR can be recommended for earlier prediction of severity of CHF.

Keywords

• сердечная недостаточность
• гомоцистеин
• метилентетрагидрофолатредуктаза
• полиморфизм с677т