Nature Communications (Oct 2022)
Remodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer
- Bihui Cao,
- Manting Liu,
- Lu Wang,
- Kangshun Zhu,
- Mingyue Cai,
- Xiaopei Chen,
- Yunfei Feng,
- Shuo Yang,
- Shengyu Fu,
- Cheng Zhi,
- Xiaodie Ye,
- Jian Zhang,
- Zhiru Zhang,
- Xin Yang,
- Ming Zhao,
- Qingde Wu,
- Linfeng Xu,
- Lili Yang,
- Hui Lian,
- Qi Zhao,
- Zhenfeng Zhang
Affiliations
- Bihui Cao
- Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University
- Manting Liu
- Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University
- Lu Wang
- Central Laboratory, the Second Affiliated Hospital of Guangzhou Medical University
- Kangshun Zhu
- Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University
- Mingyue Cai
- Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University
- Xiaopei Chen
- Central Laboratory, the Second Affiliated Hospital of Guangzhou Medical University
- Yunfei Feng
- Central Laboratory, the Second Affiliated Hospital of Guangzhou Medical University
- Shuo Yang
- Institute of Translational Medicine, Cancer Centre, Faculty of Health Sciences, University of Macau
- Shengyu Fu
- Institute of Translational Medicine, Cancer Centre, Faculty of Health Sciences, University of Macau
- Cheng Zhi
- Department of Pathology, the Second Affiliated Hospital of Guangzhou Medical University
- Xiaodie Ye
- Central Laboratory, the Second Affiliated Hospital of Guangzhou Medical University
- Jian Zhang
- Central Laboratory, the Second Affiliated Hospital of Guangzhou Medical University
- Zhiru Zhang
- Central Laboratory, the Second Affiliated Hospital of Guangzhou Medical University
- Xin Yang
- Department of Thoracic Surgery, the Second Affiliated Hospital of Guangzhou Medical University
- Ming Zhao
- Department of Interventional Radiology, Cancer Center, Sun Yat-sen University
- Qingde Wu
- Department of Radiology, Shunde Chinese Medicine Hospital, the Affiliated Hospital of Traditional Chinese Medicine University of Guangzhou
- Linfeng Xu
- Department of Interventional Therapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Lili Yang
- Department of Nutrition, School of Public Health, Sun Yat-sen University
- Hui Lian
- Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University
- Qi Zhao
- Institute of Translational Medicine, Cancer Centre, Faculty of Health Sciences, University of Macau
- Zhenfeng Zhang
- Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-022-33968-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
AXL is overexpressed and has been investigated as a therapeutic target in several cancer types, including lung cancer. Here the authors design AXLdirected CAR-T cells and show that their anti-tumor activity can be improved in combination with microwave ablation in preclinical lung cancer models.
