Salmonella typhi induced oncogenesis in gallbladder cancer: Co-relation and progression

Abstract

Generally, bacteria cause infectious diseases. The role of bacteria as a causative agent of oncogenesis or mediators has been less known and elucidated. To date, Helicobacter pylori and Chlamydia pneumonia were identified and reported as cancer-causing bacterial pathogens. Research reports also indicated Salmonella typhi as oncogenic bacteria that alter the human immune system and establishes gall bladder cancer (GBC). S. typhi releases the carcinogenic toxic molecules at the chronic phase with the asymptomatic sign and facilitates the process of transformation of normal cells into the carcinogenic cell. S. typhi infection may work as a key indicator for future GBC and lethality in planktonic conditions. The clinician identified the typhoid infection and break down the association at the primary stage in GBC. This article contains the relationship between gallbladder cancer and S. typhi and gets attention in the field of oncology because pathogen may work as a carcinogen. Because the pathogenic drive cancer field is not fully described.

Keywords

• Salmonella typhi
• Cancer
• Gallbladder
• DNA damage
• Carcinogenic