Nature Communications (Apr 2016)
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
- Valentina Gandin,
- Laia Masvidal,
- Marie Cargnello,
- Laszlo Gyenis,
- Shannon McLaughlan,
- Yutian Cai,
- Clara Tenkerian,
- Masahiro Morita,
- Preetika Balanathan,
- Olivier Jean-Jean,
- Vuk Stambolic,
- Matthias Trost,
- Luc Furic,
- Louise Larose,
- Antonis E. Koromilas,
- Katsura Asano,
- David Litchfield,
- Ola Larsson,
- Ivan Topisirovic
Affiliations
- Valentina Gandin
- Lady Davis Institute, SMBD JGH, McGill University
- Laia Masvidal
- Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet
- Marie Cargnello
- Lady Davis Institute, SMBD JGH, McGill University
- Laszlo Gyenis
- Departments of Biochemistry and Oncology, Schulich School of Medicine & Dentistry, Western University, London
- Shannon McLaughlan
- Lady Davis Institute, SMBD JGH, McGill University
- Yutian Cai
- Lady Davis Institute, SMBD JGH, McGill University
- Clara Tenkerian
- Lady Davis Institute, SMBD JGH, McGill University
- Masahiro Morita
- Department of Biochemistry, McGill University
- Preetika Balanathan
- Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Cancer Program, Monash University
- Olivier Jean-Jean
- UPMC Univ Paris 06, CNRS-UMR8256
- Vuk Stambolic
- and the Department of Medical Biophysics, Princess Margaret Cancer Centre, University Health Network, University of Toronto
- Matthias Trost
- MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
- Luc Furic
- Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Cancer Program, Monash University
- Louise Larose
- Department of Medicine, Polypeptide Laboratory, McGill University and The Research Institute of McGill University Health Centre
- Antonis E. Koromilas
- Lady Davis Institute, SMBD JGH, McGill University
- Katsura Asano
- Division of Biology, Molecular Cellular and Developmental Biology Program, Kansas State University
- David Litchfield
- Departments of Biochemistry and Oncology, Schulich School of Medicine & Dentistry, Western University, London
- Ola Larsson
- Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet
- Ivan Topisirovic
- Lady Davis Institute, SMBD JGH, McGill University
- DOI
- https://doi.org/10.1038/ncomms11127
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Ternary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and eIF4F complex assembly through eIF2β to stimulate cell proliferation.
