Prospects for the creation of antimicrobial preparations based on copper and copper oxides nanoparticles

Abstract

The spread of strains of microorganisms that are multidrug resistant to modern antimicrobial drugs is still an urgent problem in the treatment and prevention of infectious diseases and public health in general.Currently, the possibility of using metal nanopreparations in various fields of medicine is being actively studied. Nanoparticles of metals and metal oxides are promising antimicrobial agents and are attracting growing interest due to their effectiveness. Nanoscale copper metal particles have shown high antimicrobial activity againstvarious types of gram-positive and gram-negative bacteria, as well as fungi. Taking into account the potential of copper nanoparticles in antimicrobial therapy, we present an overview of the current state of research related to their antimicrobial properties, consideration of the mechanisms of action, key factors affecting antimicrobial activity, including the polymer matrix. The issues of toxicity and resistance to copper are considered. The advantage of copper nanoparticles over other metal nanoparticles is shown.The studies summarized in this review have shown the promise of copper nanoparticles in the creation of new antimicrobial drugs that can be used in the future to control, prevent, and treat various diseases.

Keywords

• copper
• copper oxides
• nanoparticles
• nanocomposites
• antimicrobial activity
• pathogenic microorganisms
• cytotoxicity