Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Brian Y. Lee; Elizabeth K. J. Hogg; Christopher R. Below; Alexander Kononov; Adrian Blanco-Gomez; Felix Heider; Jingshu Xu; Colin Hutton; Xiaohong Zhang; Tamara Scheidt; Kenneth Beattie; Angela Lamarca; Mairéad McNamara; Juan W. Valle; Claus Jørgensen

doi:10.1038/s41467-021-27607-8

Nature Communications (Dec 2021)

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Brian Y. Lee,
Elizabeth K. J. Hogg,
Christopher R. Below,
Alexander Kononov,
Adrian Blanco-Gomez,
Felix Heider,
Jingshu Xu,
Colin Hutton,
Xiaohong Zhang,
Tamara Scheidt,
Kenneth Beattie,
Angela Lamarca,
Mairéad McNamara,
Juan W. Valle,
Claus Jørgensen

Affiliations

Brian Y. Lee: Cancer Research UK Manchester Institute, The University of Manchester
Elizabeth K. J. Hogg: Cancer Research UK Manchester Institute, The University of Manchester
Christopher R. Below: Cancer Research UK Manchester Institute, The University of Manchester
Alexander Kononov: Cancer Research UK Manchester Institute, The University of Manchester
Adrian Blanco-Gomez: Cancer Research UK Manchester Institute, The University of Manchester
Felix Heider: Cancer Research UK Manchester Institute, The University of Manchester
Jingshu Xu: Cancer Research UK Manchester Institute, The University of Manchester
Colin Hutton: Cancer Research UK Manchester Institute, The University of Manchester
Xiaohong Zhang: Cancer Research UK Manchester Institute, The University of Manchester
Tamara Scheidt: Department of Molecular Biology, University of Salzburg
Kenneth Beattie: FingerPrints Proteomics Facility, College of Life Sciences, University of Dundee
Angela Lamarca: Department of Medical Oncology, The Christie NHS Foundation Trust
Mairéad McNamara: Department of Medical Oncology, The Christie NHS Foundation Trust
Juan W. Valle: Department of Medical Oncology, The Christie NHS Foundation Trust
Claus Jørgensen: Cancer Research UK Manchester Institute, The University of Manchester

DOI: https://doi.org/10.1038/s41467-021-27607-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 20

Abstract

Read online

Cancer-associated fibroblasts (CAFs) are a major component of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDA). Here the authors report the importance of macrophage-derived Oncostatin M in reprogramming CAFs to drive a pro-tumorigenic environment in PDA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal