Guideline-conform translation and cultural adaptation of the Addenbrooke’s Cognitive Examination III into German

Weiss, Björn; Grunow, Julius J.; Rosenthal, Max; Hilfrich, David; Mörgeli, Rudolf; Neuner, Bruno; Borchers, Friedrich; Kraft, Antje; Krampe, Henning; Denke, Claudia; Spies, Claudia D.

doi:10.3205/000280

GMS German Medical Science (Apr 2020)

Guideline-conform translation and cultural adaptation of the Addenbrooke’s Cognitive Examination III into German

Weiss, Björn,
Grunow, Julius J.,
Rosenthal, Max,
Hilfrich, David,
Mörgeli, Rudolf,
Neuner, Bruno,
Borchers, Friedrich,
Kraft, Antje,
Krampe, Henning,
Denke, Claudia,
Spies, Claudia D.

Affiliations

Weiss, Björn: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Grunow, Julius J.: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Rosenthal, Max: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Hilfrich, David: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Mörgeli, Rudolf: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Neuner, Bruno: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Borchers, Friedrich: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Kraft, Antje: Vision and Motor System Research Group, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Krampe, Henning: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Denke, Claudia: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Spies, Claudia D.: Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

DOI: https://doi.org/10.3205/000280
Journal volume & issue: Vol. 18
p. Doc04

Abstract

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Objective: Age-related disorders, such as dementia, significantly contribute to the global burden of disease. Adequate screening in the primary care setting is critical for early detection and proper management. The Addenbrooke’s Cognitive Examination III (ACE-III) is an open-source neuropsychological test with superior diagnostic quality in comparison to the Mini-Mental State Examination (MMSE). Our aim was to perform a guideline-conform English-German translation and cultural adaptation of the ACE-III in order to enable implementation in German-speaking countries.Methods: The translation and cultural adaptation were performed in accordance with the “Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-Reported Outcomes (PRO) Measures” from the International Society for Pharmacoeconomics and Outcome Research (ISPOR) (Wild et al. 2005). Four separate English-German translations were compiled into one German consensus translation, which was then translated back into English and compared to the original English version. After comparison, the German consensus translation was revised with emphasis on the identified differences between the English original version and the English translated version. This revised German consensus translation was subsequently evaluated for clinical applicability on a 5-point scale (0 – not applicable; 5 – applicable without any restrictions) by 20 practitioners experienced in the field of neuropsychological testing, using an anonymized, paper-based 22-item survey.Results: Nineteen of the 20 practitioners (95.0%) rated the German ACE-III translation as overall applicable. The median rating was 4.0 [IQ4.0/5.0)]. When evaluating survey items assessing the appliclity of the individual 19 subtests of the ACE-III, all of them (100%) were rated as applicable with a median rating of 4.5 [IQR (4.1/4.9)].Conclusion: The German ACE-III translation in its current form is generally applicable and can be utilized for clinical and scientific purposes.

Published in GMS German Medical Science

ISSN: 1612-3174 (Online)
Publisher: German Medical Science GMS Publishing House
Country of publisher: Germany
LCC subjects: Medicine
Website: https://www.egms.de/dynamic/en/journals/gms/index.htm

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