Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

Zhiyong Xu; Chunyi Guo; Qiaoli Ye; Yueli Shi; Yihui Sun; Jie Zhang; Jiaqi Huang; Yizhou Huang; Chunlai Zeng; Xue Zhang; Yuehai Ke; Hongqiang Cheng

doi:10.1038/s41467-021-26697-8

Nature Communications (Nov 2021)

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

Zhiyong Xu,
Chunyi Guo,
Qiaoli Ye,
Yueli Shi,
Yihui Sun,
Jie Zhang,
Jiaqi Huang,
Yizhou Huang,
Chunlai Zeng,
Xue Zhang,
Yuehai Ke,
Hongqiang Cheng

Affiliations

Zhiyong Xu: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Chunyi Guo: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Qiaoli Ye: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yueli Shi: The Fourth Affiliated Hospital, Zhejiang University School of Medicine
Yihui Sun: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Jie Zhang: Department of Urology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Jiaqi Huang: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yizhou Huang: Department of Gynecology of Women’s Hospital, Zhejiang University School of Medicine
Chunlai Zeng: Department of Cardiology, Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital
Xue Zhang: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yuehai Ke: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hongqiang Cheng: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-26697-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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SHP2 regulates pro-angiogenic VEGF-VEGFR signalling, but its role in tumour angiogenesis is unclear. Here the authors show that endothelial cell-specific deletion of SHP2 impairs tumour growth and angiogenesis in syngeneic mouse models through ASK1-c-JunSOX7 signalling axis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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