Role of matrix metalloproteinase-9 in the pathogenesis of osteoporosis in patients with chronic obstructive pulmonary disease

Abstract

Aim. To determine a relationship between matrix metalloproteinase-9 (MMP-9) activity and its tissue inhibitors TIMP-1 and 2, tumor necrosis factor-α (TNF-α), bone mineral density (BMD), and bone exchange in chronic obstructive pulmonary disease (COPD). Subjects and methods. Seventy-six patients with COPD and 20 healthy volunteers were examined using dual-energy X-ray absorptiometry n the lumbar spine (LII-LIV) and femoral neck (FN). The serum levels of MMP-9, TIMP-1 and TIMP-2, TNF-α, and Β-Crosslaps (ΒCL) were measured. Results. There was a higher MMP-9 level in COPD than that in the controls ((383.8±54.2 and 137.6±31.4 pg/ml, respectively; p

Keywords

• metalloproteinases
• tissue inhibitors of metalloproteinase
• osteoporosis
• tumor necrosis factor-α
• chronic obstructive pulmonary disease