Nature Communications (Sep 2017)
NFATc1 controls the cytotoxicity of CD8+ T cells
- Stefan Klein-Hessling,
- Khalid Muhammad,
- Matthias Klein,
- Tobias Pusch,
- Ronald Rudolf,
- Jessica Flöter,
- Musga Qureischi,
- Andreas Beilhack,
- Martin Vaeth,
- Carsten Kummerow,
- Christian Backes,
- Rouven Schoppmeyer,
- Ulrike Hahn,
- Markus Hoth,
- Tobias Bopp,
- Friederike Berberich-Siebelt,
- Amiya Patra,
- Andris Avots,
- Nora Müller,
- Almut Schulze,
- Edgar Serfling
Affiliations
- Stefan Klein-Hessling
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Khalid Muhammad
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Matthias Klein
- Institute for Immunology, University Medical Center, University of Mainz
- Tobias Pusch
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Ronald Rudolf
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Jessica Flöter
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Musga Qureischi
- Department of Medicine II, Würzburg University Hospital, Research Center for Infectious Diseases, and Interdisciplinary Center for Clinical Science Research, University Würzburg
- Andreas Beilhack
- Department of Medicine II, Würzburg University Hospital, Research Center for Infectious Diseases, and Interdisciplinary Center for Clinical Science Research, University Würzburg
- Martin Vaeth
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Carsten Kummerow
- Department of Biophysics, CIPMM, Faculty of Medicine, Saarland University
- Christian Backes
- Department of Biophysics, CIPMM, Faculty of Medicine, Saarland University
- Rouven Schoppmeyer
- Department of Biophysics, CIPMM, Faculty of Medicine, Saarland University
- Ulrike Hahn
- Cellular Neurophysiology, CIPMM, Saarland University
- Markus Hoth
- Department of Biophysics, CIPMM, Faculty of Medicine, Saarland University
- Tobias Bopp
- Institute for Immunology, University Medical Center, University of Mainz
- Friederike Berberich-Siebelt
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Amiya Patra
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Andris Avots
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Nora Müller
- Institute for Virology and Immunobiology, University of Würzburg
- Almut Schulze
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- Edgar Serfling
- Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg
- DOI
- https://doi.org/10.1038/s41467-017-00612-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.
