Homogeneity and the outcome of clinical trials: An appraisal of the outcome of recent clinical trials on endovascular intervention in acute ischemic stroke

Abstract

Clinical trials that allow significant heterogeneity of population or interventions often result in uncertain outcomes. In this paper, we review the outcomes of five recent trials of endovascular interventions in acute ischemic stroke in the context of the neutral results of previous large clinical trials on the subject.

Keywords

• Endovascular intervention in stroke
• ESCAPE
• EXTEND-IA
• mechanical thrombectomy
• MR CLEAN
• SWIFT-PRIME
• TREVO
• REVASCAT
• SOLITAIRE
• STENT RETREIVER