International Journal of Infectious Diseases (May 2020)
A first case of meningitis/encephalitis associated with SARS-Coronavirus-2
- Takeshi Moriguchi,
- Norikazu Harii,
- Junko Goto,
- Daiki Harada,
- Hisanori Sugawara,
- Junichi Takamino,
- Masateru Ueno,
- Hiroki Sakata,
- Kengo Kondo,
- Natsuhiko Myose,
- Atsuhito Nakao,
- Masayuki Takeda,
- Hirotaka Haro,
- Osamu Inoue,
- Katsue Suzuki-Inoue,
- Kayo Kubokawa,
- Shinji Ogihara,
- Tomoyuki Sasaki,
- Hiroyuki Kinouchi,
- Hiroyuki Kojin,
- Masami Ito,
- Hiroshi Onishi,
- Tatsuya Shimizu,
- Yu Sasaki,
- Nobuyuki Enomoto,
- Hiroshi Ishihara,
- Shiomi Furuya,
- Tomoko Yamamoto,
- Shinji Shimada
Affiliations
- Takeshi Moriguchi
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan; Corresponding author.
- Norikazu Harii
- Department of Community and Family Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Junko Goto
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Daiki Harada
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Hisanori Sugawara
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Junichi Takamino
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Masateru Ueno
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Hiroki Sakata
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Kengo Kondo
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Natsuhiko Myose
- Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Atsuhito Nakao
- Dean, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Masayuki Takeda
- Department of Urology, University of Yamanashi, Graduate School of Medical Sciences, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Hirotaka Haro
- Department of Orthopaedic Surgery, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Osamu Inoue
- Division of Infection Control and Prevention, University of Yamanashi Hospital, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Katsue Suzuki-Inoue
- Department of Clinical and Laboratory Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Kayo Kubokawa
- Department of Nursing, University of Yamanashi Hospital, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Shinji Ogihara
- Central Laboratory Unit/Division of Infection Control and Prevention, University of Yamanashi Hospital, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Tomoyuki Sasaki
- Department of Clinical and Laboratory Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Hiroyuki Kinouchi
- Department of Neurosurgery, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Hiroyuki Kojin
- Department of Clinical Quality and Medical Safety Management, University of Yamanashi Hospital, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Masami Ito
- Department of Clinical Quality and Medical Safety Management, University of Yamanashi Hospital, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Hiroshi Onishi
- Department of Radiology, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Tatsuya Shimizu
- Department of Radiology, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Yu Sasaki
- Department of Radiology, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Nobuyuki Enomoto
- First Department of Internal Medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Hiroshi Ishihara
- Second Department of Internal medicine, University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Shiomi Furuya
- Department of Clinical Quality and Medical Safety Management, University of Yamanashi Hospital, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Tomoko Yamamoto
- Department of Clinical Quality and Medical Safety Management, University of Yamanashi Hospital, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Shinji Shimada
- President, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409-3898 Japan
- Journal volume & issue
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Vol. 94
pp. 55 – 58
Abstract
Novel coronavirus (SARS-Coronavirus-2:SARS-CoV-2) which emerged in Wuhan, China, has spread to multiple countries rapidly. We report the first case of meningitis associated with SARS-CoV-2 who was brought in by ambulance due to a convulsion accompanied by unconsciousness. He had never been to any foreign countries. He felt generalized fatigue and fever (day 1). He saw doctors nearby twice (day 2 and 5) and was prescribed Laninamivir and antipyretic agents, His family visited his home and found that he was unconsciousness and lying on the floor in his vomit. He was immediately transported to this hospital by ambulance (day 9). Under emergency transport, he had transient generalized seizures that lasted about a minute. He had obvious neck stiffness. The specific SARS-CoV-2 RNA was not detected in the nasopharyngeal swab but was detected in a CSF. Anti- HSV 1 and varicella-zoster IgM antibodies were not detected in serum samples. A brain MRI showed hyperintensity along the wall of right lateral ventricle and hyperintense signal changes in the right mesial temporal lobe and hippocampus, suggesting the possibility of SARS-CoV-2 meningitis. This case warns the physicians of patients who have CNS symptoms.
