Numerical Solution and Analysis for Acute and Chronic Hepatitis B

Abstract

In this article, we present the transmission dynamic of the acute and chronic hepatitis B epidemic problem to control the spread of hepatitis B in a community. In order to do this, first we present sensitivity analysis of the basic reproduction number R0. We develop a unconditionally convergent nonstandard finite difference scheme by applying Mickens approach φ(h) = h + O(h^2) instead of h to control the spread of this infection, treatment and vaccination to minimize the number of acute infected, chronically infected with hepatitis B individuals and maximize the number of susceptible and recovered individuals. The stability analysis of the scheme has been developed by theorems which shows the both stable locally and globally. Comparison is also made with standard nonstandard finite difference scheme. Finally numerical simulations are also established to investigate the influence of the system parameter on the spread of the disease.