Nature Communications (Sep 2017)
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
- Ting-Wen Chen,
- Chi-Ching Lee,
- Hsuan Liu,
- Chi-Sheng Wu,
- Curtis R. Pickering,
- Po-Jung Huang,
- Jing Wang,
- Ian Yi-Feng Chang,
- Yuan-Ming Yeh,
- Chih-De Chen,
- Hsin-Pai Li,
- Ji-Dung Luo,
- Bertrand Chin-Ming Tan,
- Timothy En Haw Chan,
- Chuen Hsueh,
- Lichieh Julie Chu,
- Yi-Ting Chen,
- Bing Zhang,
- Chia-Yu Yang,
- Chih-Ching Wu,
- Chia-Wei Hsu,
- Lai-Chu See,
- Petrus Tang,
- Jau-Song Yu,
- Wei-Chao Liao,
- Wei-Fan Chiang,
- Henry Rodriguez,
- Jeffrey N. Myers,
- Kai-Ping Chang,
- Yu-Sun Chang
Affiliations
- Ting-Wen Chen
- Molecular Medicine Research Center, Chang Gung University
- Chi-Ching Lee
- Molecular Medicine Research Center, Chang Gung University
- Hsuan Liu
- Molecular Medicine Research Center, Chang Gung University
- Chi-Sheng Wu
- Molecular Medicine Research Center, Chang Gung University
- Curtis R. Pickering
- Departments of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center
- Po-Jung Huang
- Molecular Medicine Research Center, Chang Gung University
- Jing Wang
- Departments of Biostatistics, the University of Texas MD Anderson Cancer Center
- Ian Yi-Feng Chang
- Molecular Medicine Research Center, Chang Gung University
- Yuan-Ming Yeh
- Molecular Medicine Research Center, Chang Gung University
- Chih-De Chen
- Molecular Medicine Research Center, Chang Gung University
- Hsin-Pai Li
- Molecular Medicine Research Center, Chang Gung University
- Ji-Dung Luo
- Molecular Medicine Research Center, Chang Gung University
- Bertrand Chin-Ming Tan
- Molecular Medicine Research Center, Chang Gung University
- Timothy En Haw Chan
- Graduate Institute of Biomedical Sciences, Chang Gung University
- Chuen Hsueh
- Pathology Core of the Molecular Medicine Research Center, Chang Gung University
- Lichieh Julie Chu
- Molecular Medicine Research Center, Chang Gung University
- Yi-Ting Chen
- Molecular Medicine Research Center, Chang Gung University
- Bing Zhang
- Department of Molecular and Human Genetics Lester & Sue Smith Breast Center, Baylor College of Medicine
- Chia-Yu Yang
- Molecular Medicine Research Center, Chang Gung University
- Chih-Ching Wu
- Molecular Medicine Research Center, Chang Gung University
- Chia-Wei Hsu
- Molecular Medicine Research Center, Chang Gung University
- Lai-Chu See
- Department of Public Health, Chang Gung University
- Petrus Tang
- Molecular Medicine Research Center, Chang Gung University
- Jau-Song Yu
- Molecular Medicine Research Center, Chang Gung University
- Wei-Chao Liao
- Molecular Medicine Research Center, Chang Gung University
- Wei-Fan Chiang
- Department of Oral & Maxillofacial Surgery, Chi-Mei Medical Center
- Henry Rodriguez
- Office of Cancer Clinical Proteomics Research, National Cancer Institute, US National Institutes of Health, Bethesda
- Jeffrey N. Myers
- Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital at Linkou
- Kai-Ping Chang
- Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital at Linkou
- Yu-Sun Chang
- Molecular Medicine Research Center, Chang Gung University
- DOI
- https://doi.org/10.1038/s41467-017-00493-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Oral squamous cell carcinoma is a prevalent malignancy in Taiwan. Here, the authors show that OSCC in Taiwanese show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression of A3A, which is shown to be of clinical prognostic relevance.
