Resveratrol, curcumin and gallic acid attenuate glyoxal-induced damage to rat renal cells

Mahmoud Hashemzaei; Kaveh Tabrizian; Zeinab Alizadeh; Sedigheh Pasandideh; Ramin Rezaee; Charalampos Mamoulakis; Aristidis Tsatsakis; Zoi Skaperda; Demetrios Kouretas; Jafar Shahraki

Toxicology Reports (Jan 2020)

Resveratrol, curcumin and gallic acid attenuate glyoxal-induced damage to rat renal cells

Mahmoud Hashemzaei,
Kaveh Tabrizian,
Zeinab Alizadeh,
Sedigheh Pasandideh,
Ramin Rezaee,
Charalampos Mamoulakis,
Aristidis Tsatsakis,
Zoi Skaperda,
Demetrios Kouretas,
Jafar Shahraki

Affiliations

Mahmoud Hashemzaei: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran; Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran
Kaveh Tabrizian: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran; Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran
Zeinab Alizadeh: Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran
Sedigheh Pasandideh: Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran
Ramin Rezaee: Clinical Research Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author at: Clinical Research Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Charalampos Mamoulakis: Department of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece
Aristidis Tsatsakis: Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003, Greece
Zoi Skaperda: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, 41500, Greece
Demetrios Kouretas: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, 41500, Greece
Jafar Shahraki: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran; Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran; Corresponding author at: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.

Journal volume & issue: Vol. 7
pp. 1571 – 1577

Abstract

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Glyoxal (GO), a by-product of glucose auto-oxidation, is involved in the glycation of proteins/ lipids and formation of advanced glycation (AGE) and lipoxidation (ALE) end products. AGE/ALE were shown to contribute to diabetic complications development/progression such as nephropathy. Diabetic nephropathy progression has an oxidative nature. Given the antioxidant effects of polyphenols, potential protective effects of resveratrol, curcumin and gallic acid, in rat renal cells treated with GO, were evaluated in the present work. According to our results, incubation of GO with the cells reduced their viability and led to membrane lysis, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial membrane potential collapse, and lysosomal membrane leakage. These findings were prevented by pre-treatment with resveratrol, curcumin and gallic acid. Mitochondrial and lysosomal toxic interactions appear to worsen oxidative stress/cytotoxicity produced by GO. Resveratrol, curcumin and gallic acid inhibited ROS formation and attenuated GO-induced renal cell death.

Published in Toxicology Reports

ISSN: 2214-7500 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Public aspects of medicine: Toxicology. Poisons
Website: http://www.journals.elsevier.com/toxicology-reports/

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