Study of features of drug metabolism in patients with chronic liver diseases

Abstract

In one-stage opened research activity of isoenzymes СYР3А4 and CYP2C9 of system of biotransformation of medicines at patients with chronic diffusive liver diseases — residents of Volgograd and the Volgograd region is defined. It is established that the greatest decrease in activity of isoenzyme СYР3А4 is connected with chronic virus hepatitis C (for 57 % from normal values), in other groups as decrease in activity of an isoenzyme is noted: at primary biliary cirrhosis (for 43,5 %), alcoholic liver disease (for 39 %) and nonalcoholic fatty liver disease (fatty liver) (for 33 %). At all patients with chronic diffusive liver diseases as decrease in activity of an isoenzyme of CYP2C9 is noted. In group of chronic virus hepatitis C (for 48 % from normal values), primary biliary cirrhosis (for 41,2 %), nonalcoholic fatty liver disease (fatty liver) (for 23,4 %), alcoholic liver disease (for 20,5 %).

Keywords

• хронические диффузные заболевания печени
• активность
• изофермент cyp3a4
• изофермент cyp2c9
• индивидуализация фармакотерапии