Research and Reports in Urology (Nov 2020)
Infiltrating Treg and Th17 Cells of the Prostate Hypertrophy Gland Associated with Propionibacterium Acnes Infection
Abstract
Sebastian Radej,1 Paweł Płaza,2 Alina Olender,3 Monika Szewc,1 Krzysztof Bar,2 Ryszard Maciejewski1 1Department of Normal Anatomy, Medical University of Lublin, Lublin, Poland; 2Urology and Urological Oncology, Medical University of Lublin, Lublin, Poland; 3Chair and Department of Medical Microbiology, Medical University of Lublin, Lublin, PolandCorrespondence: Sebastian RadejDepartment of Normal Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090, Lublin, PolandTel/Fax +4881448 6020Email [email protected]: The aim of the study was to evaluate prostate cell infiltration by CD4(+)IL-17(+) and Treg cells in BPH and PCa patients depending on P. acnes infection in the prostate gland.Patients and Methods: Prostate fragments were collected from 54 patients with PCa and 34 patients with BPH. Rapid ID 32 was used to identify the bacteria. Cells were analyzed by flow cytometry BD FACSCanto II. Statistical analysis was performed using Statistica 7 software (TIBCO Software Inc, USA).Results: P. acnes was detected in 35% of patients with PCa and 41% of individuals with BPH. The infiltration of CD4(+)IL-17(+) and Treg cells was statistically significantly higher (P = 0.001) in patients with BPH and positive for P. acnes. A statistically considerably higher (P = 0.001) infiltration of Treg cells in treated for PCa with P.acnes infection was also demonstrated.Conclusion: Prostatitis caused by P. acnes may contribute to the development of BPH and PCa.Keywords: P. acnes, Treg cells, Th17 cells, benign prostatic hyperplasia, prostate cancer
