Gastroenterologìa (Oct 2020)
Clinical and genetic characteristics of patients with obesity and non-alcoholic fatty liver disease
Abstract
Backgrounds. Currently, the rs1801282 (Pro12Ala) polymorphism in PPAR-γ2 (peroxisome proliferator-activated receptor gamma) gene is important for the pathogenesis of both obesity and non-alcoholic fatty liver disease (NAFLD). However, the clinical and laboratory characteristics in Ukrainian patients with combined pathology have not yet been studied based on this polymorphism. The purpose was to study the clinical and laboratory features of patients with obesity and NAFLD depending on rs1801282 polymorphism in PPAR-γ2 gene. Materials and methods. The study involved 123 patients with obesity 1–3 classes and NAFLD. All patients underwent a molecular genetic study of rs1801282 polymorphism in PPAR-γ2 gene, as well as anthropometric measurements, laboratory and instrumental examinations (including ultrasound (US) steatometry). Results. The study revealed in patients with CG and GG genotypes rs1801282 polymorphism of PPAR-γ2 gene significantly much higher levels of body mass index (p = 0.03), fasting glucose (p = 0.02), insulin (p < 0.0001), and C-peptide (p = 0.02), ALT (p = 0.04), GGTP (p < 0.0001), total cholesterol (p = 0.03), triglycerides (p = 0.002), low-density lipoprotein cholesterol (p = 0.004), very low-density lipoprotein cholesterol (p = 0.001), atherogenic factor (p < 0.0001), except for levels of CAP (p = 0.002), stimulated insulin (p < 0.0001), serum uric acid (p = 0.008), and high-density lipoprotein cholesterol (p < 0.0001) that were significantly less higher compared to CC genotype. Conclusions. In Ukrainians with a combined course of obesity and NAFLD, the carriers of the G allele rs1801282 polymorphism of PPAR-γ2 gene have been shown to have significant metabolic differences that might be associated with protection against the development of steatosis and type 2 diabetes, however increase cardiovascular risk.
Keywords
