Communications Biology (Sep 2022)

Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway

  • Miki Inoue,
  • Takashi Baba,
  • Fumiya Takahashi,
  • Miho Terao,
  • Shogo Yanai,
  • Yuichi Shima,
  • Daisuke Saito,
  • Kei Sugihara,
  • Takashi Miura,
  • Shuji Takada,
  • Mikita Suyama,
  • Yasuyuki Ohkawa,
  • Ken-ichirou Morohashi

DOI
https://doi.org/10.1038/s42003-022-03941-5
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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Investigation of fetal Leydig progenitors shows that thymosin β10 (Tmsb10) suppresses the RAS/ERK pathway, inducing progenitor differentiation into fetal Leydig cells.