Validated Ultraviolet High-Performance Liquid Chromatography Method for Post-mortem 5-Hydroxy-indoleacetic Acid Measurement in Human Cerebrospinal Fluid

Divya Bhushan; Jayanthi Yadav; Arneet Arora; Dhruv Agrawal; Achala Apte

doi:10.1055/s-0043-1774378

Journal of Laboratory Physicians ()

Validated Ultraviolet High-Performance Liquid Chromatography Method for Post-mortem 5-Hydroxy-indoleacetic Acid Measurement in Human Cerebrospinal Fluid

Divya Bhushan,
Jayanthi Yadav,
Arneet Arora,
Dhruv Agrawal,
Achala Apte

Affiliations

Divya Bhushan: Department Forensic Medicine and Toxicology, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
Jayanthi Yadav: Department Forensic Medicine and Toxicology, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
Arneet Arora: Department Forensic Medicine and Toxicology, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
Dhruv Agrawal: ORCiD; Department of Medical Laboratory Sciences, LPU, Phagwara, Punjab, India
Achala Apte: Department of Biological Sciences, IISER, Bhopal, Madhya Pradesh, India

DOI: https://doi.org/10.1055/s-0043-1774378

Abstract

Read online

Objective The objective of this study was to develop an ultraviolet high-performance liquid chromatography (UV-HPLC) method for the measurement of 5-hydroxyindoleacetic acid (5-HIAA) in human cerebrospinal fluid (CSF) as a potential biomarker for neurological and psychiatric illnesses, including depressive disorders with suicidal behavior.

Published in Journal of Laboratory Physicians

ISSN: 0974-2727 (Print); 0974-7826 (Online)
Publisher: Thieme Medical and Scientific Publishers Pvt. Ltd.
Country of publisher: India
LCC subjects: Medicine
Website: https://www.thieme.in/journal-of-laboratory-physicians

About the journal

Abstract

Keywords