Molecules (Apr 2015)

A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012

  • Wamtinga Richard Sawadogo,
  • Rainatou Boly,
  • Claudia Cerella,
  • Marie Hélène Teiten,
  • Mario Dicato,
  • Marc Diederich

DOI
https://doi.org/10.3390/molecules20047097
Journal volume & issue
Vol. 20, no. 4
pp. 7097 – 7142

Abstract

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Although considerable effort and progress has been made in the search for new anticancer drugs and treatments in the last several decades, cancer remains a major public health problem and one of the major causes of death worldwide. Many sources, including plants, animals, and minerals, are of interest in cancer research because of the possibility of identifying novel molecular therapeutics. Moreover, structure-activity-relationship (SAR) investigations have become a common way to develop naturally derived or semi-synthetic molecular analogues with improved efficacy and decreased toxicity. In 2012, approximately 138 molecules from marine sources, including isolated compounds and their associated analogues, were shown to be promising anticancer drugs. Among these, 62% are novel compounds. In this report, we review the marine compounds identified in 2012 that may serve as novel anticancer drugs.

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