Factors affecting mortality and morbidity in acute pancreatitis

Abstract

We aimed to reveal the parameters that may be early predictors of mortality and morbidity by examining the data of patients with acute pancreatitis. In this study, demographic, clinical and biochemical parameters of 273 patients treated with the diagnosis of acute pancreatitis between 2010 and 2016 were scanned. Age, sex, comorbidity, history of operation, application method, clinical information about the etiology of pancreatitis, hemogram and biochemical parameters, Ranson values, morbidity and mortality findings were recorded. Of the 273 patients, whose mean age ranged from 18 to 98 (mean±sd: 56.94±19.21), 105 were male and 168 were female. Mortality developed in 3% of the patients (n=8), and a statistically significant difference was found between patients with and without mortality concerning age, the time between symptom and admission, presence of comorbidity, operation, Ranson scores, hypocalcemia and CRP values. Morbidity developed in 49.1% (n=134) of the patients, and when the patients with and without morbidity were compared, statistically significant difference was found concerning the female sex, presence of comorbidity, hyperglycemia, neutrophil to lymphocyte ratio (NLR), BUN, ALT, GGT, CRP, BUN, Ca values and Ranson scores. According to the Logistic Regression Analysis of the parameters that give significant results, Ranson 48th-hour measurements, admission time and age can predict mortality best, respectively, while 48th-hour Ranson value, CRP and NLR can best predict morbidity, respectively. [Med-Science 2022; 11(2.000): 566-73]

Keywords

• acute pancreatitis
• mortality
• morbidity