The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives

Abstract

Abstract The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ38 accumulated around Aβ42.

Keywords

• Amyloid β protein
• Senile plaque