KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis

Abstract

It is unclear whether there is a progenitor/stem cell in the basal layer of the urothelium in the bladder. Here, the authors identify Keratin14 positive cells that can regenerate the bladder in both a natural and injury-induced manner, and following neoplastic transformation, can give rise to tumours.