Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

Onisha Patel; Michael D. W. Griffin; Santosh Panjikar; Weiwen Dai; Xiuquan Ma; Howard Chan; Celine Zheng; Ashleigh Kropp; James M. Murphy; Roger J. Daly; Isabelle S. Lucet

doi:10.1038/s41467-017-01279-9

Nature Communications (Oct 2017)

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

Onisha Patel,
Michael D. W. Griffin,
Santosh Panjikar,
Weiwen Dai,
Xiuquan Ma,
Howard Chan,
Celine Zheng,
Ashleigh Kropp,
James M. Murphy,
Roger J. Daly,
Isabelle S. Lucet

Affiliations

Onisha Patel: The Walter and Eliza Hall Institute of Medical Research
Michael D. W. Griffin: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Santosh Panjikar: Australian Synchrotron
Weiwen Dai: The Walter and Eliza Hall Institute of Medical Research
Xiuquan Ma: Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University
Howard Chan: Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University
Celine Zheng: The Walter and Eliza Hall Institute of Medical Research
Ashleigh Kropp: The Walter and Eliza Hall Institute of Medical Research
James M. Murphy: The Walter and Eliza Hall Institute of Medical Research
Roger J. Daly: Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University
Isabelle S. Lucet: The Walter and Eliza Hall Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-017-01279-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Pseudokinases lack kinase activity, yet they impact cellular physiology through the regulation of bona fide signaling kinases. Here the authors describe the structure of the SgK223 pseudokinase and its adjacent domains, and identify regulatory interfaces required for self-assembly and downstream signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal