PDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity

• Farid A. Siddiqui,
• Catharina Alam,
• Petja Rosenqvist,
• Mikko Ora,
• Ahmed Sabt,
• Ganesh babu Manoharan,
• Lakshman Bindu,
• Sunday Okutachi,
• Marie Catillon,
• Troy Taylor,
• Omaima M. Abdelhafez,
• Harri Lönnberg,
• Andrew G. Stephen,
• Anastassios C. Papageorgiou,
• Pasi Virta,
• Daniel Abankwa

Affiliations

Farid A. Siddiqui

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland

Catharina Alam

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland

Petja Rosenqvist

Department of Chemistry, University of Turku, Turku, Finland

Mikko Ora

Department of Chemistry, University of Turku, Turku, Finland

Ahmed Sabt

Department of Chemistry, University of Turku, Turku, Finland

Ganesh babu Manoharan

Cancer Cell Biology and Drug Discovery Group, Life Sciences Research Unit, University of Luxembourg, Esch-sur-Alzette, Luxembourg

Lakshman Bindu

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States

Sunday Okutachi

Cancer Cell Biology and Drug Discovery Group, Life Sciences Research Unit, University of Luxembourg, Esch-sur-Alzette, Luxembourg

Marie Catillon

Cancer Cell Biology and Drug Discovery Group, Life Sciences Research Unit, University of Luxembourg, Esch-sur-Alzette, Luxembourg

Troy Taylor

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States

Omaima M. Abdelhafez

Chemistry of Natural Compounds Department, National Research Centre, Giza, Egypt

Harri Lönnberg

Department of Chemistry, University of Turku, Turku, Finland

Andrew G. Stephen

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States

Anastassios C. Papageorgiou

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland

Pasi Virta

Department of Chemistry, University of Turku, Turku, Finland

Daniel Abankwa

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland