DEVELOPMENT OF TECHNOLOGY AND METHODS OF CONTROL OF BIFUNCTIONAL OINTMENT

Abstract

A new bifunctional ointment with chondroitin sulfate and celecoxib on a hydrophilic base was developed. The optimum conditions of the technology and technological properties of the ointment were determined. The techniques for quantitativecontrol of active components in a bifunctional ointment are developed. Quantitative determination of chondroitin sulfate in an ointment was conducted by turbidimetric titration. A relative error of determination with confidence probability P=95% is not more than 2,01%. Quantitative determination of celecoxib was conducted by spectrophotometry. A relative error of determination with confidence probability P=95% is not more than 3,22%.

Keywords

• bifunctional ointment
• chondroitin sulfate
• celecoxib
• polyethylene glycol
• dimethylsulfoxide