An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine

Guang Song; Guohua Wang; Ximei Luo; Ying Cheng; Qifeng Song; Jun Wan; Cedric Moore; Hongjun Song; Peng Jin; Jiang Qian; Heng Zhu

doi:10.1038/s41467-021-20950-w

Nature Communications (Feb 2021)

An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine

Guang Song,
Guohua Wang,
Ximei Luo,
Ying Cheng,
Qifeng Song,
Jun Wan,
Cedric Moore,
Hongjun Song,
Peng Jin,
Jiang Qian,
Heng Zhu

Affiliations

Guang Song: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine
Guohua Wang: School of Computer Science and Technology, Harbin Institute of Technology
Ximei Luo: School of Computer Science and Technology, Harbin Institute of Technology
Ying Cheng: Department of Human Genetics, Emory University School of Medicine
Qifeng Song: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine
Jun Wan: Department of Ophthalmology, Johns Hopkins University School of Medicine
Cedric Moore: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine
Hongjun Song: Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania
Peng Jin: Department of Human Genetics, Emory University School of Medicine
Jiang Qian: Department of Ophthalmology, Johns Hopkins University School of Medicine
Heng Zhu: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-20950-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Identifying readers of epigenetic marks is a critical step for understanding the role of epigenetic marks in biology. Here, the authors applied DAPPL, an all-to-all approach to profile the interactions between TFs and epigenetic modified DNA libraries.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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