The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations

Lalitha Ammadu Kolahalam; K.R.S. Prasad; P. Murali Krishna; N. Supraja; S. Shanmugan

Heliyon (Jun 2022)

The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations

Lalitha Ammadu Kolahalam,
K.R.S. Prasad,
P. Murali Krishna,
N. Supraja,
S. Shanmugan

Affiliations

Lalitha Ammadu Kolahalam: Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 522502, Andhra Pradesh, India
K.R.S. Prasad: Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 522502, Andhra Pradesh, India; Corresponding author.
P. Murali Krishna: Department of Chemistry, Ramaiah Institute of Technology (Autonomous Institute, Affiliated to VTU), Bangalore, 560054, Karnataka, India; Corresponding author.
N. Supraja: Acharya N G Ranga Agricultural University, Nanotechnology Laboratory, RARS, Tirupati, 517502, Andhra Pradesh, India
S. Shanmugan: Research Centre for Solar Energy, Department of Physics, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 522502, Andhra Pradesh, India

Journal volume & issue: Vol. 8, no. 6
p. e09726

Abstract

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The paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts Ocimum sanctum and Saussurea lappa as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained from powder X-ray diffraction spectroscopy, Fourier Transmission Infrared, Ultraviolet-Visible spectra, Field Emission Scanning Electron Microscopy images, Energy Dispersive X-ray analysis and Dynamic light scattering techniques and data reveal that the average size of CuO Nps was 103.4 nm. The result of antibacterial and antifungal activities for concentrations 50, 100, and 170 ppm indicate that NPs may exhibit appreciable activity at higher (170 ppm) concentrations. The MTT cytotoxic assay studies of Chinese Hamster Ovary (CHO) cell lines showed a Half-maximal inhibitory concentration (IC50) value of 4.14 μg/mL.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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