Nature Communications (Sep 2017)

Organocatalytic synthesis of chiral tetrasubstituted allenes from racemic propargylic alcohols

  • Deyun Qian,
  • LinLin Wu,
  • Zhenyang Lin,
  • Jianwei Sun

DOI
https://doi.org/10.1038/s41467-017-00251-x
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Axially chiral allenes that are normally present in natural products, bioactive molecules, organocatalysts, and functional materials are usually produced from propargylic derivatives. Here, the authors show direct use of propargylic alcohols for catalytic asymmetric allene synthesis.